No. 04The targets
The 30 receptors, enzymes, transporters and axes our compounds bind to. 20 of them adapt. This page is the inventory of what adapts, how it adapts, and how long it takes to recover — the timing data that drives every cycle on the previous three pages.
§ 0How to read a target entry
For every adapting target, we record how it adapts (the mechanism), how fast it desensitizes (the time constant), and how long the full reset takes (the recovery window) — each rated for evidence quality.
The reset window is what determines whether a compound goes on the Short Cycle or the Long Cycle.
adenosine-a1-a2a · receptor
receptor downregulation
trka-trkb · receptor
receptor downregulation
dectin-1 · receptor
receptor downregulation
cyp19a1-aromatase · enzyme
enzyme upregulation
hpa-axis · axis
axis set point drift
hpg-axis · axis
axis set point drift
keap1-nrf2-are · signaling complex
feedback loop desensitization
nfkb · signaling complex
feedback loop desensitization
adenosine-a1-a2a · receptor
receptor downregulation
muscarinic-m1 · receptor
receptor downregulation
mt1-mt2 · receptor
receptor downregulation
5-ht1a-2a · receptor
receptor downregulation
gaba-a · receptor
receptor internalization
nicotinic-alpha7 · receptor
receptor downregulation
ache · enzyme
enzyme upregulation
mao-b · enzyme
enzyme upregulation
aadc · enzyme
substrate competition
gcl · enzyme
feedback loop desensitization
ampk-kinase · enzyme
feedback loop desensitization
sirt1 · enzyme
cofactor depletion
mitochondrial-etc-complex · signaling complex
feedback loop desensitization
slc6a8 · transporter
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
taut-slc6a6 · transporter
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
nad-pool · substrate pool
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
collagen-substrate · substrate pool
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
electrolyte-pool · substrate pool
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
omega-spm-pool · substrate pool
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
keratin-substrate · substrate pool
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
cofactor-pool · substrate pool
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
vdr-nuclear · receptor
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
enos-no-pathway · enzyme
Pharmacologically stable. No meaningful adaptation in response to sustained exposure — daily dosing is appropriate.
By the numbers
Total targets
30
Across receptors, enzymes, transporters, axes, signaling complexes and substrate pools.
Adapt with use
20
These are the targets that drive the cycling schedule.
Clinical evidence
6
Adapting targets with human RCT or longitudinal reset data.
Preclinical evidence
12
Strong animal / in-vitro data; human data suggestive but partial.
The targets classified by mechanistic inference are disclosed on their entries above. We cycle them — but we want you to know the empirical timing data is thinner than for the clinical-rated ones.