PSK
Polysaccharide-K (Krestin)
Why this matters
- № 01Extensively researched for immune system support*
Trametes versicolor
One of the most researched medicinal mushrooms, named for its colorful, fan-shaped appearance. Extensively studied for its immune-supporting properties.

Trametes versicolorBotanical illustration
§ 1The molecules
Polysaccharide-K (Krestin)
Why this matters
Polysaccharopeptide
Why this matters
β-(1→3)(1→6)-glucan
Why this matters
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
§ 2Receipts
“Phase I clinical trial (n=11) evaluating Trametes versicolor (turkey tail) mushroom at escalating doses (3, 6, or 9 g/day) in women with breast cancer post-radiation. Turkey tail polysaccharopeptide (PSP) supplementation for 6 weeks significantly enhanced NK cell activity and increased CD8+ T-cell and CD19+ B-cell counts in a dose-dependent manner.”Torkelson et al., ISRN Oncology, 2012
“Systematic review of 13 RCTs evaluating polysaccharide-K (PSK) and polysaccharopeptide (PSP) from Trametes versicolor as adjuvant cancer therapy. PSK (3 g/day) alongside chemotherapy significantly improved 5-year survival rates in gastric and colorectal cancer patients, mediated through beta-glucan activation of innate and adaptive immunity.”Fritz et al., Integrative Cancer Therapies, 2015
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Browse the full library§ 4Cross-references

Hericium erinaceus
A distinctive white, shaggy mushroom used for centuries in traditional Chinese medicine.

Ganoderma lucidum
Known as the 'mushroom of immortality' in traditional Chinese medicine, Reishi has been used for over 2,000 years to support longevity and overall wellness.

Cordyceps militaris
A unique fungus traditionally used by Tibetan herdsmen and Olympic athletes alike.
Turkey Tail has the most extensive human clinical data of any functional mushroom — but most of it came from oncology research. Here's what PSK does, and why the gut-immune connection is the angle that matters most for healthy people.
The functional mushroom category has a quality problem disguised as a variety problem. Understanding why requires going one level deeper — into the cell wall, the extraction process, and the molecular structures that actually do something.
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