No.01
Melatonin
Why this matters
- № 01Signals the body to prepare for sleep*
- № 02Supports healthy circadian rhythm*
- № 03Helps reduce time to fall asleep*
The Library · Vol. 01Entry No. 31· Chapter 05
Melatonin
N-acetyl-5-methoxytryptamine
The body's natural sleep hormone, produced by the pineal gland in response to darkness. Melatonin regulates the circadian rhythm and signals to the body that it's time to sleep.
1
Active compounds
3
In our products
2
Clinical citations
05
Sleep & Mood
N-acetyl-5-methoxytryptamineBotanical illustration
§ 1The molecules
Active compounds.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
§ 2Receipts
What the research shows.
“Meta-analysis of 19 RCTs (n=1,683) examining melatonin for primary sleep disorders. Melatonin significantly reduced sleep onset latency by 7.06 minutes (p<0.001), increased total sleep time by 8.25 minutes (p=0.013), and improved overall sleep quality (p<0.001) versus placebo. Higher doses and longer durations showed greater effects.”Ferracioli-Oda et al., PLoS ONE, 2013
“Dose-response meta-analysis of 26 RCTs (n=1,689) optimizing melatonin as a sleep-promoting agent. Sleep onset latency reduction and total sleep time increase peaked at 4 mg/day. Administration 3 hours before desired bedtime was significantly more effective than the standard 30-minute pre-bedtime dosing (p=0.023).”Scarpelli et al., Journal of Pineal Research, 2024
From the Library · Vol. 01
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