5-Hydroxytryptophan
Why this matters
- № 01Direct precursor to serotonin - converts to serotonin in the brain*
- № 02Supports positive mood and emotional well-being*
- № 03Promotes restful sleep by converting to melatonin at night*
Griffonia simplicifolia
A woody climbing shrub native to West and Central Africa, where its seeds have been used in traditional medicine for generations. Griffonia simplicifolia seeds are the primary natural source of 5-HTP (5-hydroxytryptophan) — the direct precursor to serotonin, the neurotransmitter central to mood, sleep, and emotional well-being.

Griffonia simplicifoliaBotanical illustration
§ 1The molecules
Why this matters
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
§ 2Receipts
“In a recent clinical trial, older adults taking 100mg of 5-HTP daily for 12 weeks showed improvements in both cognitive scores and mood markers. As the direct precursor to serotonin, 5-HTP supports the brain's natural production of this important neurotransmitter.”Nutrients, 2025
Every compound in your stack — sourced, dosed, and cited. No proprietary blends. Browse the science behind the bottles.
We publish every dose, every source, every paper we leaned on. An informed customer is our only kind.
Browse the full libraryThis is not medical advice and not a replacement for professional mental health care. It is a clear-eyed look at the natural compounds with clinical evidence for anxiety — how they work, what they don't do, who they're appropriate for, and one critical drug interaction that can be life-threatening. If you're experiencing severe or persistent anxiety, please work with a healthcare provider.
Elevated resting heart rate. Jaw tension you notice at 5pm. Racing thoughts at bedtime. These aren't personality quirks — they're involuntary physiological stress responses. Here's what's driving each one.
Tryptophan is the dietary precursor to serotonin, but most of it never becomes serotonin — the kynurenine pathway diverts up to 95% toward immune and NAD+ functions. 5-HTP bypasses this fork entirely, entering the serotonin synthesis pathway one enzymatic step downstream. Here's why that matters for mood, sleep, and why combining it with SSRIs is dangerous.
— End of entry
Browse the products it’s in, or build a stack around the goal it serves best.