The Library · Vol. 01Entry No. 109· Chapter 11

N-Acetyl Cysteine

N-Acetyl-L-Cysteine

A stable, acetylated form of the sulfur amino acid L-cysteine and the direct precursor to glutathione — the body's master antioxidant. Originally developed as a mucolytic and approved as the standard-of-care antidote for acetaminophen toxicity, NAC's redox-modulating role has made it one of the most studied compounds in cellular health and detoxification research.

1
Active compounds
0
In our products
2
Clinical citations
11
Longevity & Cellular Energy
N-Acetyl Cysteine (N-Acetyl-L-Cysteine)

N-Acetyl-L-CysteineBotanical illustration

§ 1The molecules

Active compounds.

No.01

N-Acetyl Cysteine (NAC)

N-Acetyl-L-Cysteine

Why this matters

  • 01Direct precursor to glutathione — the body's primary intracellular antioxidant*
  • 02Supports liver detoxification pathways and hepatocyte resilience*
  • 03Promotes a healthy respiratory tract via mucolytic action*
  • 04Modulates oxidative stress in a wide range of cellular contexts*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

§ 2Receipts

What the research shows.

Systematic review and meta-analysis of 11 RCTs (n=575) evaluating NAC for chronic obstructive pulmonary disease. NAC (typically 600 mg 1–3×/day for 3–12 months) significantly reduced exacerbation frequency and improved symptom scores versus placebo, with effects attributed to mucolytic action and restoration of pulmonary glutathione.Cazzola et al., European Respiratory Review, 2015
Mechanistic and clinical review of NAC's redox pharmacology. NAC supplies cysteine — the rate-limiting substrate for glutathione synthesis — and directly scavenges reactive oxygen species via its free thiol. Bioavailability is moderate (4–10%) but sustained dosing reliably elevates intracellular glutathione, restoring redox balance in oxidative-stress states.Aldini et al., Free Radical Research, 2018
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