The Library · Vol. 01Entry No. 102· Chapter 11

Japanese Knotweed

Polygonum cuspidatum

A fast-growing plant native to East Asia, used for centuries in Traditional Chinese and Japanese medicine. Japanese Knotweed is the most concentrated natural source of trans-resveratrol — the stilbenoid compound studied extensively for its role in activating longevity-linked sirtuin pathways.

1
Active compounds
2
In our products
2
Clinical citations
11
Longevity & Cellular Energy
Japanese Knotweed (Polygonum cuspidatum) — botanical watercolor illustration

Polygonum cuspidatumBotanical illustration

§ 1The molecules

Active compounds.

1 compound · 3 statements

No.01

Trans-Resveratrol

Why this matters

  • № 01Activates SIRT1 - the 'longevity gene' pathway*
  • № 02Supports cardiovascular health and healthy blood flow*
  • № 03Powerful antioxidant that supports cellular health*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

§ 2Receipts

What the research shows.

2 citations

“Systematic review and meta-analysis of 17 RCTs (n=736) examining resveratrol supplementation on inflammatory markers. Resveratrol significantly reduced TNF-alpha (p=0.002) and hs-CRP (p=0.033) versus placebo, supporting its use as an adjunct anti-inflammatory agent in metabolic diseases.”Koushki et al., Clinical Therapeutics, 2018
“Updated meta-analysis of 35 RCTs evaluating resveratrol's effect on C-reactive protein. Resveratrol significantly reduced both hs-CRP (-0.40 mg/L, p=0.01) and CRP (-0.31 mg/L, p<0.001). Subgroup analysis showed that supplementation lasting 10 weeks or longer had the greatest effect.”Gorabi et al., Phytotherapy Research, 2021

§ 3Where it lives

Find Japanese Knotweed in

2 products

Resveratrol
Resveratrol
600mg(50% Trans-Resveratrol (300mg))Above cycling threshold
$20.92$27.90
NAD+
NAD+
150 mg(98% Resveratrol)Below cycling threshold
$23.17$30.90
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180Compounds
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Lion's Mane Mushroom botanical illustration
№ 01 · CH.01

Lion's Mane Mushroom

Hericium erinaceus

A distinctive white, shaggy mushroom used for centuries in traditional Chinese medicine.

HericenonesErinacinesβ-(1→3)(1→6)-glucan
Reishi Mushroom botanical illustration
№ 02 · CH.01

Reishi Mushroom

Ganoderma lucidum

Known as the 'mushroom of immortality' in traditional Chinese medicine, Reishi has been used for over 2,000 years to support longevity and overall wellness.

Ganoderic acidsβ-(1→3)(1→6)-glucanPolysaccharides
Ashwagandha botanical illustration
№ 11 · CH.02

Ashwagandha

Withania somnifera

One of the most important herbs in Ayurvedic medicine, used for over 3,000 years.

WithanolidesWithaferin ASitoindosides
Rhodiola Rosea botanical illustration
№ 12 · CH.02

Rhodiola Rosea

Rhodiola rosea

A powerful adaptogen that grows in cold, mountainous regions of Europe and Asia.

RosavinsSalidroside
Bacopa botanical illustration
№ 17 · CH.03

Bacopa

Bacopa monnieri

An ancient Ayurvedic herb known as 'Brahmi', used for thousands of years to enhance memory and learning.

Bacosides
Chinese Club Moss botanical illustration
№ 18 · CH.03

Chinese Club Moss

Huperzia serrata

A primitive, slow-growing moss native to mountain forests of China and Southeast Asia, used in Traditional Chinese Medicine for centuries.

Huperzine A
Bee Bread botanical illustration
№ 19 · CH.04

Bee Bread

Fermented Bee Pollen

Bee bread is pollen that has been fermented by bees using honey and their own enzymes.

Digestive EnzymesAmino Acids
Royal Jelly botanical illustration
№ 20 · CH.04

Royal Jelly

Apis mellifera secretion

The exclusive food of queen bees, who live 40x longer than worker bees.

10-Hydroxy-2-decenoic acidRoyalactin
Valerian Root botanical illustration
№ 22 · CH.05

Valerian Root

Valeriana officinalis

A flowering plant native to Europe and Asia, Valerian has been used since ancient Greece and Rome to promote relaxation and restful sleep.

Valerenic AcidIsovaleric Acid
Lavender botanical illustration
№ 23 · CH.05

Lavender

Lavandula angustifolia

A fragrant herb used for thousands of years to promote relaxation and sleep.

LinaloolLinalyl Acetate
Horsetail Extract botanical illustration
№ 30 · CH.06

Horsetail Extract

Equisetum arvense

An ancient plant dating back to prehistoric times, Horsetail is one of the richest natural sources of silica.

Silicon Dioxide
Fo-Ti botanical illustration
№ 31 · CH.06

Fo-Ti

Polygonum multiflorum

A revered herb in Traditional Chinese Medicine, known as 'He Shou Wu' meaning 'black-haired Mr.

StilbenesAnthraquinones

We publish every dose, every source, every paper we leaned on. An informed customer is our only kind.

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— End of entry

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