Nicotinamide Adenine Dinucleotide
A coenzyme found in every living cell, essential for converting nutrients into cellular energy. NAD+ levels naturally decline with age, making supplementation a key strategy in longevity research.
Nicotinamide Adenine DinucleotideBotanical illustration
§ 1The molecules
Nicotinamide Adenine Dinucleotide
Why this matters
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
§ 2Receipts
“Randomized, multicenter, double-blind, placebo-controlled, dose-dependent RCT of 80 healthy middle-aged adults. Oral NMN (300, 600, or 900 mg/day) for 60 days significantly increased blood NAD+ levels at all doses (p<0.001). The 600 and 900 mg groups showed significantly improved six-minute walking distance and biological age scores versus placebo.”Yi et al., GeroScience, 2023
“Systematic review and meta-analysis of 12 RCTs (n=513) on oral NMN supplementation in adults. NMN significantly elevated blood NAD+ levels versus placebo. However, most clinically relevant metabolic outcomes (fasting glucose, lipids) did not significantly differ, suggesting benefits may be more prominent in NAD+-depleted populations.”Zhong et al., Critical Reviews in Food Science and Nutrition, 2024
Every compound in your stack — sourced, dosed, and cited. No proprietary blends. Browse the science behind the bottles.
We publish every dose, every source, every paper we leaned on. An informed customer is our only kind.
Browse the full libraryThe supplement aisle is designed to overwhelm you into buying nothing or buying everything. Neither is correct. Here's a tiered framework — start at the foundation, add based on your goal, and only advance when the previous tier is habitual. Each tier is complete on its own. You don't need Tier 3 to benefit from Tier 1.
NAD+ sits at the intersection of three aging hallmarks: mitochondrial dysfunction, DNA damage accumulation, and epigenetic drift. Understanding why it declines — and what actually works to restore it — requires tracing the molecule through every pathway that depends on it.
— End of entry
Browse the products it’s in, or build a stack around the goal it serves best.
