The Library · Vol. 01Entry No. 133· Chapter 13

Black Pepper

Piper nigrum

More than just a spice - Black Pepper contains piperine, a powerful bioavailability enhancer that significantly increases the absorption of other nutrients and compounds.

1
Active compounds
9
In our products
2
Clinical citations
13
Vitamins & Enhancers
Black Pepper (Piper nigrum)

Piper nigrumBotanical illustration

§ 1The molecules

Active compounds.

No.01

Piperine

Why this matters

  • 01Increases bioavailability of other compounds by up to 2000%*
  • 02Enhances nutrient absorption in the gut*
  • 03Supports healthy metabolism*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

§ 2Receipts

What the research shows.

Landmark crossover study in humans (n=8 per group) demonstrating that co-administration of 20 mg piperine with 2 g curcumin increased curcumin bioavailability by 2,000%. A separate arm showed 20 mg piperine increased beta-carotene bioavailability by 60%. The mechanism involves inhibition of hepatic and intestinal glucuronidation.Shoba et al., Planta Medica, 1998
Review of piperine's pharmacokinetic enhancement effects across multiple human and animal studies. Piperine (5-20 mg) significantly increases the bioavailability of curcumin, resveratrol, beta-carotene, CoQ10, and several pharmaceutical drugs by inhibiting CYP3A4, CYP1A1, and P-glycoprotein efflux transporters.Kesarwani & Gupta, Asian Pacific Journal of Tropical Biomedicine, 2013
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