Resveratrol
Polygonum cuspidatum
A polyphenol found in red wine, grapes, and Japanese Knotweed. Resveratrol has been extensively studied for its potential to activate sirtuins - proteins associated with longevity and healthy aging.
Active Compounds
Trans-Resveratrol
- Activates SIRT1 - the 'longevity gene' pathway*
- Supports cardiovascular health and healthy blood flow*
- Powerful antioxidant that supports cellular health*
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
What the Research Shows
Systematic review and meta-analysis of 17 RCTs (n=736) examining resveratrol supplementation on inflammatory markers. Resveratrol significantly reduced TNF-alpha (p=0.002) and hs-CRP (p=0.033) versus placebo, supporting its use as an adjunct anti-inflammatory agent in metabolic diseases.
Source: Koushki et al., Clinical Therapeutics, 2018
Learn more →Updated meta-analysis of 35 RCTs evaluating resveratrol's effect on C-reactive protein. Resveratrol significantly reduced both hs-CRP (-0.40 mg/L, p=0.01) and CRP (-0.31 mg/L, p<0.001). Subgroup analysis showed that supplementation lasting 10 weeks or longer had the greatest effect.
Source: Gorabi et al., Phytotherapy Research, 2021
Learn more →Products with Resveratrol
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Resveratrol and Longevity: Separating Sirtuin Hype from Clinical Reality
Resveratrol had a dramatic rise as the longevity supplement. Then the human data arrived. Here's an honest read of what the mechanism actually is, where the mouse-to-human translation failed, and what realistic expectations look like.
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